Element AVITI24™ System
Single-cell and Spatial Multiomics Meet Sequencing
Discover AVITI24™, the first benchtop system that combines cellular-level multi-omics analysis and NGS sequencing in a single, powerful, flexible, high-performance platform. Designed to explore biological complexity at unprecedented resolution, AVITI24 redefines the standard for cellular research.
AVITI24 takes cellular research to a new level, combining single-cell and spatial analysis in a single platform that uncovers the molecular complexity within each individual cell, in its structural context.
A new era in cell mapping
Thanks to the proprietary Teton™ CytoProfiling technology, AVITI24 allows the simultaneous analysis of RNA, proteins and morphology in situ, up to 2 million cells per experiment. In just 24 hours, obtain a complete and high-resolution molecular profile, directly from fixed and permeabilized cells, without the need for library preparation.
- In situ RNA-Seq: up to 350 transcripts at subcellular resolution
- Spatial proteomics: fino a 50 proteine, incluse fosfoproteine
- Cell morphology: imaging mitochondria, nucleus, Golgi, membrane, and cytoskeleton
- Advanced automation: only 45 minutes of hands-on time
Sequencing and multiomics in a single platform
AVITI24 is compatible with a wide range of NGS applications: exomes, transcriptomes, RNA-Seq, metagenomics, targeted analysis. All this thanks to the Avidite Base Chemistry (ABC) sequencing chemistry, which guarantees high quality, low costs and exceptional sensitivity.
Fast and flexible workflow
Il sistema include due flow cell indipendenti con imaging fino a 10 cm² e supporta sia cellule in sospensione che coltivate direttamente sulle flow cell. Le opzioni pre-rivestite o personalizzabili garantiscono la massima compatibilità con diversi tipi cellulari.
Targeted Multi-Omics Panels
AVITI24 launches with two human panels focused on key signaling pathways:
- MAPK Cell Cycle: study of the cell cycle
- MAPK Apoptosis: analysis of apoptosis mechanisms
Each panel allows the detection of up to 350 RNA targets and 50 proteins, with high multiplexing capacity and integrated analysis.
Expandable and future-ready
AVITI24 is designed to evolve. Additional panels, customizable options and applications are coming soon, such as:
- Targeted and untargeted in situ RNA-Seq
- Unbiased 3’ sequencing
- CRISPR guide mapping directly in situ
Aviti. Your science can’t wait!
Click on the questions to get the answers
AVITI24™ is the first benchtop platform that integrates next-generation sequencing (NGS) and in situ multi-omic analysis at the single cell level in a single system. Thanks to Teton™ CytoProfiling technology, AVITI24 allows to simultaneously explore RNA, proteins (including phosphoproteins) and cell morphology, with subcellular resolution, directly on the sample.
It means being able to observe simultaneously, in the same cell and in the same spatial context, multiple levels of biological information: transcriptomics (RNA), proteomics (proteins and phosphoproteins) and morphology. It is not just about measuring quantities, but about seeing where these molecules are located in the cell and how they interact, maintaining the architecture of the tissue or culture.
Teton™ CytoProfiling is Element Biosciences’ proprietary technology that enables in situ, single-cell multi-omic analysis. In a single 24-hour run, up to 2 million cells can be analyzed, detecting RNA, proteins, and morphological components at subcellular resolution, without the need for extraction, dissociation, or library prep.
With AVITI24 you can obtain, from the same cell:
- The expression of up to 350 transcripts (RNA)
- The profile of up to 50 proteins, including phosphorylated ones
- Morphological imaging of nucleus, membrane, mitochondria, Golgi, endoplasmic reticulum, actin
- The spatial context of information: where molecules and structures are located
- The ability to automatically segment cells and assign RNA/proteins to specific cells
- In situ and single-cell: no loss of spatial information or heterogeneity
- Automated workflow: only 45 minutes of hands-on time
- High-resolution imaging: up to 20 cm² area per run
- Automatic cell segmentation and assignment, supported by AI
- Integrated analysis: RNA, protein and morphology from the same sample
- Results in 24 hours
AVITI24 is ideal for:
- Time course studies
- Drug screening and combinatorial drug testing
- Advanced cell phenotyping
- Cell lineage tracking
- Cell cycle analysis and apoptosis (MAPK)
- Pathway and stress response studies
AVITI24 currently offers two fixed panels for human applications:
- MAPK Cell Cycle
- MAPK Apoptosis
Both support integrated analysis of RNA (up to 350 targets) and proteins (up to 50), with morphology in 6 channels. Customizable panels and new applications are under development, including targeted/untargeted in situ RNA-Seq and CRISPR guide mapping.
AVITI24 is compatible with:
- Suspension cells
- Adherent cells grown directly on the flow cell
- Fixed and permeabilized samples
Teton™ flow cells are available both pre-coated (PLL) and customizable, to ensure maximum compatibility with different cell types and experimental conditions.
The complete workflow requires:
- Less than 1 hour of sample preparation
- 24 hours for the entire acquisition and primary analysis
- Output directly viewable via integrated software (Element CytoCanvas™)
Yes, the system created by Element Biosciences is designed to be scalable and modular. No instrument is abandoned: thanks to an upgradeable approach, it is possible to evolve an AVITI™ or AVITILT™ into AVITI24™, integrating the necessary modules to enable Teton™ CytoProfiling technology and in situ multiomics.
This approach guarantees a sustainable investment over time, with the possibility of expanding the functionality of the instrument as scientific needs grow, without having to replace the platform.